N-[2-(diphenylphosphoryl)phenyl]-2-(diphenylthiophosphoryl)acetamide

Base Information

• Chemical Name: N-[2-(diphenylphosphoryl)phenyl]-2-(diphenylthiophosphoryl)acetamide
• CAS No.: 1428259-29-3
• Molecular Formula: C₃₂H₂₇NO₂P₂S
• Molecular Weight: 551.585
• Mol file: 1428259-29-3.mol

Synonyms:N-[2-(diphenylphosphoryl)phenyl]-2-(diphenylthiophosphoryl)acetamide

Chemical Property of N-[2-(diphenylphosphoryl)phenyl]-2-(diphenylthiophosphoryl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(diphenylphosphoryl)phenyl]-2-(diphenylthiophosphoryl)acetamide

There total 3 articles about N-[2-(diphenylphosphoryl)phenyl]-2-(diphenylthiophosphoryl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-chloro-N-[2-(diphenylphosphoryl)phenyl]acetamide (1428259-14-6) + diphenylphosphane sulfide (6591-07-7) → N-[2-(diphenylphosphoryl)phenyl]-2-(diphenylthiophosphoryl)acetamide (1428259-29-3)

Guidance literature:

diphenylphosphane sulfide; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.25h; Inert atmosphere;

2-chloro-N-[2-(diphenylphosphoryl)phenyl]acetamide; In tetrahydrofuran; mineral oil; at 40 ℃; for 2h;

DOI:10.1016/j.poly.2012.12.025

Reference yield:

2-aminophenyl(diphenyl)phosphine oxide (23081-74-5) → N-[2-(diphenylphosphoryl)phenyl]-2-(diphenylthiophosphoryl)acetamide (1428259-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / chloroform / 0.5 h / 0 - 5 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / Inert atmosphere

2.2: 2 h / 40 °C

With sodium hydride; triethylamine; In tetrahydrofuran; chloroform; mineral oil;

DOI:10.1016/j.poly.2012.12.025

Reference yield:

(2-diphenylphosphino)benzeneamine (65423-44-1) → N-[2-(diphenylphosphoryl)phenyl]-2-(diphenylthiophosphoryl)acetamide (1428259-29-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dihydrogen peroxide / water; chloroform / 2.5 h / 20 - 50 °C

2.1: triethylamine / chloroform / 0.5 h / 0 - 5 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.25 h / Inert atmosphere

3.2: 2 h / 40 °C

With dihydrogen peroxide; sodium hydride; triethylamine; In tetrahydrofuran; chloroform; water; mineral oil;

DOI:10.1016/j.poly.2012.12.025

upstream raw materials:

2-chloro-N-[2-(diphenylphosphoryl)phenyl]acetamide

diphenylphosphane sulfide

2-aminophenyl(diphenyl)phosphine oxide

(2-diphenylphosphino)benzeneamine

Downstream raw materials:

C₃₂H₂₆ClNO₂P₂PdS