23081-74-5Relevant articles and documents
Chelate complexes of phosphorus-nitrogen ligands. 1. Deprotonation, cis-trans isomerism, and anion-catalyzed isomerization in platinum(II) complexes of (o-aminophenyl)diphenylphosphine
Cooper, Mervyn K.,Michael Downes
, p. 880 - 884 (1978)
The new hybrid ligand (o-aminophenyl)diphenylphosphine (PNH2) has been synthesized and bis-ligand chelate complexes of platinum(II) have been prepared. Facile deprotonation of the coordinated amino group has allowed the preparation of both cis and trans isomers of [Pt(PNH2)2]X2, [Pt(PNH-)(PNH2)]X, and [Pt(PNH-)2] (X- is a noncoordinating anion and PNH- is the conjugate base of PNH2). The stereochemistries have been assigned using 31P NMR spectroscopy. The first observation of anion-catalyzed isomerization in square-planar complexes is reported.
Chelation-Assisted Interrupted Copper(I)-Catalyzed Azide-Alkyne-Azide Domino Reactions: Synthesis of Fully Substituted 5-Triazenyl-1,2,3-triazoles
García López, Jesús,Iglesias, María José,López Ortiz, Fernando,Navarro, Yolanda
supporting information, p. 334 - 339 (2021/01/13)
We describe the synthesis of 1,4-(disubstituted)-5-triazenyl-1,2,3-triazoles through a ligand-free domino copper(I)-catalyzed azide-alkyne-azide process of chelating aryl azides bearing N-P═O, P═O, and SO3H groups at the ortho position with a wide variety of acetylenes. DFT calculations reveal that Cu-chelation is a crucial factor in the interception of the CuAAC intermediate by the azide. The crystal structure of the catalytic species has been determined by X-ray diffraction.
Synthesis and biological evaluation of vanadium complexes as novel anti-tumor agents
Lu, Ling-Pan,Suo, Feng-Zhi,Feng, Ya-Li,Song, Li-Li,Li, Ying,Li, Yang-Jie,Wang, Kai-Ti
, p. 1 - 10 (2019/05/15)
A class of vanadium complexes were prepared and investigated for their antiproliferative effects by MTT assay. The structure-activity relationship was extensively studied through the ligand variation. The results showed that the synthetic vanadium complexes demonstrated moderate to good antiproliferative activities against the four cancer cell lines including MGC803, EC109, MCF7 and HepG2, respectively. Of note was that most of the complexes showed preferential growth inhibitory activity to some degree toward gastric cancer line MGC803. Among them, complex 19 exhibited the most and broad-spectrum proliferative inhibition against the tested cell lines. In addition, mechanism studies illustrated that complex 19 could prevent the colony formation, migration and EMT process, as well as induce apoptosis of MGC803 cells. Furthermore, Western blot experiments revealed that the expression of apoptosis-related proteins changed, including up-regulation of Bax, PARP and caspase-3/9, as well as down-regulation of Bcl-2.
Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity
Alonso, Concepción,Fuertes, María,Martín-Encinas, Endika,Selas, Asier,Rubiales, Gloria,Tesauro, Cinzia,Knudssen, Birgitta K.,Palacios, Francisco
, p. 225 - 237 (2018/03/09)
This work describes the synthesis of 1,2,3,4-tetrahydroquinolinylphosphine oxides, phosphanes and phosphine sulfides as well as that of quinolinylphosphine oxides and phosphine sulfides, which were synthesized in good to high overall yield. The synthetic
