2-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol

Base Information

• Chemical Name: 2-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol
• CAS No.: 150852-11-2
• Molecular Formula: C₁₇H₂₂ClN₃O₃
• Molecular Weight: 351.833

Synonyms:2-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol

Chemical Property of 2-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol

Chemical Property:

Purity/Quality:

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Technology Process of 2-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol

There total 4 articles about 2-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1,2,4-Triazole (288-88-0) + 2-(4-Chlorophenyl)-2-<1-(tetrahydropyran-2-yloxy)ethyl>oxirane (132507-86-9) → 2-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol (150852-11-2)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1248/cpb.38.2476

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 2-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol (150852-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h / Ambient temperature

2: 1) NaH / 1) DMSO, rt, 1 h, 2) DMSO, rt, 1 h

3: 84 percent / tert-BuOK / dimethylformamide / 1 h / 100 °C

With potassium tert-butylate; sodium hydride; pyridinium p-toluenesulfonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2476

Reference yield:

1-(4-chlorophenyl)-2-hydroxypropan-1-one (49656-24-8) → 2-(4-Chloro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol (150852-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 5 h / Ambient temperature

2: 1) NaH / 1) DMSO, rt, 1 h, 2) DMSO, rt, 1 h

3: 84 percent / tert-BuOK / dimethylformamide / 1 h / 100 °C

With potassium tert-butylate; sodium hydride; pyridinium p-toluenesulfonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2476

upstream raw materials:

1,2,4-Triazole

2-(4-Chlorophenyl)-2-<1-(tetrahydropyran-2-yloxy)ethyl>oxirane

3,4-dihydro-2H-pyran

1-(4-chlorophenyl)-2-hydroxypropan-1-one

Downstream raw materials:

[(4S,5S)-5-(4-Chloro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-(2-fluoro-4-trifluoromethyl-phenyl)-methanone

(E)-1-[(4S,5S)-5-(4-Chloro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-3-(4-trifluoromethyl-phenyl)-propenone

Methanesulfonic acid (1S,2S)-2-(4-chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

1-[(4S,5S)-5-(4-Chloro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole

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