2-(9H-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-tert-butyl ester

Base Information

Chemical Name:2-(9H-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-tert-butyl ester
CAS No.:868754-95-4
Molecular Formula:C₃₄H₃₇NO₆
Molecular Weight:555.671
Hs Code.:

2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-<i>tert</i>-butyl ester

Synonyms:2-(9H-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-tert-butyl ester

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Chemical Property of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-tert-butyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-tert-butyl ester

There total 3 articles about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 32400-25-2
t-butyl pent-4-enoate

: 477578-53-3
benzyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoate

: 868754-95-4
2-(9H-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-tert-butyl ester

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 2h; Heating;
DOI:10.1021/ol0520222

Reference yield:

: 100-39-0
benzyl bromide

: 868754-95-4
2-(9H-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NaHCO₃ / dimethylformamide

2: 74 percent / (PCy₃)Cl₂(C₃H₅N₂Mes₂)Ru=CHPh / CH₂Cl₂ / 2 h / Heating

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0520222

Reference yield:

: 146549-21-5
2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid

: 868754-95-4
2-(9H-fluoren-9-ylmethoxycarbonylamino)-oct-4-enedioic acid 1-benzyl ester 8-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NaHCO₃ / dimethylformamide

2: 74 percent / (PCy₃)Cl₂(C₃H₅N₂Mes₂)Ru=CHPh / CH₂Cl₂ / 2 h / Heating

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0520222