1-Benzyl-1H-tetrazole-5-carboxylic acid [2-carbamoyl-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

Base Information

Chemical Name:1-Benzyl-1H-tetrazole-5-carboxylic acid [2-carbamoyl-3-(4-methyl-piperazin-1-yl)-phenyl]-amide
CAS No.:77245-55-7
Molecular Formula:C₂₁H₂₄N₈O₂
Molecular Weight:420.474
Hs Code.:

Synonyms:1-Benzyl-1H-tetrazole-5-carboxylic acid [2-carbamoyl-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

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Chemical Property of 1-Benzyl-1H-tetrazole-5-carboxylic acid [2-carbamoyl-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

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Technology Process of 1-Benzyl-1H-tetrazole-5-carboxylic acid [2-carbamoyl-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

There total 5 articles about 1-Benzyl-1H-tetrazole-5-carboxylic acid [2-carbamoyl-3-(4-methyl-piperazin-1-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63005-71-0
1-benzyl-1H-tetrazole-5-carboxylic acid ethyl ester

: 77245-55-7
1-Benzyl-1H-tetrazole-5-carboxylic acid [2-carbamoyl-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / KOH / ethanol

2: oxalyl chloride, pyridine / benzene / 0.5 h / 15 °C

3: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; potassium hydroxide; oxalyl dichloride; In ethanol; dichloromethane; benzene;
DOI:10.1021/jm00138a021

Reference yield:

: 63005-72-1
1-benzyl-1H-tetrazole-5-carboxylic acid potassium salt

: 77245-55-7
1-Benzyl-1H-tetrazole-5-carboxylic acid [2-carbamoyl-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, pyridine / benzene / 0.5 h / 15 °C

2: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; oxalyl dichloride; In dichloromethane; benzene;
DOI:10.1021/jm00138a021

Reference yield:

: 7142-72-5
N-benzyloxamic acid ethyl ester

: 77245-55-7
1-Benzyl-1H-tetrazole-5-carboxylic acid [2-carbamoyl-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: PCl₅, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: hydrazoic acid / CH₂Cl₂; benzene / 1.) RT, 1 h, 2.) reflux, 5 h

3: 90 percent / KOH / ethanol

4: oxalyl chloride, pyridine / benzene / 0.5 h / 15 °C

5: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; potassium hydroxide; hydrogen azide; oxalyl dichloride; phosphorus pentachloride; In ethanol; dichloromethane; benzene;
DOI:10.1021/jm00138a021