63005-71-0Relevant articles and documents
PROCESS AND INTERMEDIATES FOR PREPARING BENZOXAZEPINES
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Page/Page column 49, (2018/09/25)
Disclosed is a new process and intermediates for preparing benzoxazepines of Formula (I): (I) wherein Q is, and A, L, B, RA and m are as defined herein.
Ionic liquid-assisted synthesis of 5-monoand 1,5-disubstituted tetrazoles
Epishina, Margarita A.,Kulikov, Alexander S.,Ignat'Ev, Nikolai V.,Schulte, Michael,Makhova, Nina N.
experimental part, p. 334 - 336 (2012/01/14)
Interaction of aliphatic, aromatic and heteroaromatic nitriles with NaN3 or activated nitriles with organic azides in ionic liquids affords the corresponding 5-mono- and 1,5-disubstituted tetrazoles, ionic liquids functioning both as a reaction medium and as a catalyst.
Cu2(OTf)2-catalyzed and microwave-controlled preparation of tetrazoles from nitriles and organic azides under mild, safe conditions
Bosch, Lluis,Vilarrasa, Jaume
, p. 3926 - 3930 (2008/03/11)
Avoiding hazards: Cu2(OTf)2·C 6H6 (OTf = O3SCF3) is the catalyst of choice for the [3+2] cycloaddition of organic azides and ethyl cyanoformate or related nitriles (see scheme; PG = protect
A click chemistry approach to tetrazoles by huisgen 1,3-dipolar cycloaddition: Synthesis of 5-acyltetrazoles from azides and acyl cyanides
Demko, Zachary P.,Sharpless, K. Barry
, p. 2113 - 2116 (2007/10/03)
Click chemistry: Acyl cyanides react with alkyl azides in high yield by heating at 120-130°C (see scheme). The reactions are run neat, and the workup is simple. When p-nitrophenyl cyanoformate is used as the dipolarophile, the resulting tetrazoles are act
2'Hydroxy tetrazole-5-carboxanilides and anti-allergic use thereof
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, (2008/06/13)
New tetrazole derivatives of the general formula: STR1 [wherein R1 represents a halogen atom, a straight- or branched-chain alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino, or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), a straight- or branched-chain alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl or alkanoylamino group containing from 2 to 6 carbon atoms, a cycloalkylcarbonyl group containing from 3 to 8 carbon atoms in the cycloalkyl moiety, or a hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl or aroyl group, or a group of the formula: (wherein R2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 5 carbon atoms, an aryl, aralkyl or trifluoromethyl group, or a cycloalkyl group containing from 3 to 8 carbon atoms, and R3 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atoms optionally substituted by a phenyl group, or represents an aryl group optionally substituted by one or more substituents selected from halogen atoms and straight- or branched-chain alkyl and alkoxy groups containing from 1 to 6 carbon atoms and hydroxy, trifluoromethyl and nitro groups), and m represents zero or an integer 1, 2 or 3, the substituents R1 being the same or different when m represents 2 or 3] possess pharmacological properties, in particular properties of value in the treatment of allergic conditions.
N-Benzyl and N-substituted benzyl tetrazole-5-carboxylic acids and the preparation thereof
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, (2008/06/13)
N-Protected-tetrazole-5-carboxylic acid derivatives of the formula: STR1 in which R is --OM, halo or lower alkoxy wherein M is hydrogen, an alkali metal or an alkaline earth metal; and R1 is phenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl or 2,4,6
5-Tetrazolecarboxamides and Their Salts: New Orally Active AntiAllergy Agents
Klaubert, Dieter H.,Sellstedt, John H.,Guinosso, Charles J.,Bell, Stanley C.,Capetola, Robert J.
, p. 748 - 752 (2007/10/02)
A new series of orally active antiallergy agents, tetrazole-5-carboxamides, has been prepared by acylation of substituted anilines or aminopyridines with 1-benzyl- or 4-(methoxybenzyl)-5-tetrazolecarbonyl chloride and subsequent removal of the benzyl subs
Tetrazole-5-carboxamide derivatives
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, (2008/06/13)
Anti-allergic agents of N-aromatic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: STR1 in which R1 is --CN or --CONH2 ; R2 is hydrogen, lower alkyl, lower alkoxy, halo, polyhalo(lower)alkyl, lower alkyl carbonyl or carb(lower)alkoxy; X is --CH2 --, --O--, or STR2 where R3 is lower alkyl; and R4 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof.
1H-tetrazole-5-carboxamides
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, (2008/06/13)
Anti-allergic agents of N-aromatic and N-heterocyclic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: STR1 in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 6-(lower)alkyl-2-pyridyl, 3-cyano
Morpholine containing tetrazole-5-carboxamide derivatives
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, (2008/06/13)
Anti-allergic agents of N-aromatic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: STR1 in which R1 is --CN or --CONH2 ; R2 is hydrogen, lower alkyl, lower alkoxy, halo, polyhalo(lower)alkyl,
