Technology Process of Methyl-3,6-diacetyl-5-(benzyloxy)-1,2-dihydro-2-hydroxy-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat
There total 10 articles about Methyl-3,6-diacetyl-5-(benzyloxy)-1,2-dihydro-2-hydroxy-8-methyl-3H,6H-pyrrolo<3,2-e>indol-1-carboxylat which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
tetrahydrofuran; dimethyl sulfoxide;
for 6h;
Ambient temperature;
DOI:10.1002/hlca.19890720717
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 97 percent / N-bromosuccinimide / acetonitrile / 0.17 h / 55 °C
2: 87 percent / 4-(dimethylamino)pyridine / 48 h / 100 °C
3: 98 percent / NaOH / methanol / 2 h / Ambient temperature
4: 60 percent / Na2CO3 / dimethylformamide / 20 h / Heating
5: 74 percent / Bu3N, Pd(OAc)2P(Tol3)2 / toluene / 48 h / Heating
6: hydrogen, conc. NH4OH, DMSO / 5 percent Pt/C / tetrahydrofuran / 1 h / 15 °C
7: NaHCO3 / tetrahydrofuran; H2O / 1 h / 0 °C
8: 49 percent / Et3N / tetrahydrofuran; dimethylsulfoxide / 6 h / Ambient temperature
With
dmap; ammonium hydroxide; sodium hydroxide; N-Bromosuccinimide; tributyl-amine; Pd(OAc)2P(Tol3)2; hydrogen; sodium hydrogencarbonate; sodium carbonate; dimethyl sulfoxide; triethylamine;
platinum on activated charcoal;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/hlca.19890720717
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 87 percent / 4-(dimethylamino)pyridine / 48 h / 100 °C
2: 98 percent / NaOH / methanol / 2 h / Ambient temperature
3: 60 percent / Na2CO3 / dimethylformamide / 20 h / Heating
4: 74 percent / Bu3N, Pd(OAc)2P(Tol3)2 / toluene / 48 h / Heating
5: hydrogen, conc. NH4OH, DMSO / 5 percent Pt/C / tetrahydrofuran / 1 h / 15 °C
6: NaHCO3 / tetrahydrofuran; H2O / 1 h / 0 °C
7: 49 percent / Et3N / tetrahydrofuran; dimethylsulfoxide / 6 h / Ambient temperature
With
dmap; ammonium hydroxide; sodium hydroxide; tributyl-amine; Pd(OAc)2P(Tol3)2; hydrogen; sodium hydrogencarbonate; sodium carbonate; dimethyl sulfoxide; triethylamine;
platinum on activated charcoal;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19890720717
