6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid

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Chemical Name:6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid
CAS No.:1374673-17-2
Molecular Formula:C₁₇H₁₃FN₄O₂
Molecular Weight:324.314
Hs Code.:

Synonyms:6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid

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Chemical Property of 6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid

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Technology Process of 6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid

There total 5 articles about 6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1374672-49-7
6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid methyl ester

: 1374673-17-2
6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid

Guidance literature:: 6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid methyl ester; With methanol; lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In water;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1374673-17-2
6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: water; tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -75 °C / Inert atmosphere

3.2: 1 h / -75 - 20 °C

4.1: acetic acid / acetic anhydride / 144 h / 120 °C

5.1: water; methanol; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

With methanol; n-butyllithium; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; acetic acid; N-ethyl-N,N-diisopropylamine; copper(l) iodide; In tetrahydrofuran; hexane; acetic anhydride; N,N-dimethyl-formamide;

Reference yield:

: 1374645-73-4
4-(4-fluorophenyl)-1-methyl-1H-1,2,3-triazole

: 1374673-17-2
6-{(E)-2-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-vinyl}-nicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -75 °C / Inert atmosphere

1.2: 1 h / -75 - 20 °C

2.1: acetic acid / acetic anhydride / 144 h / 120 °C

3.1: water; methanol; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

With methanol; n-butyllithium; lithium hydroxide monohydrate; water; acetic acid; In tetrahydrofuran; hexane; acetic anhydride;