6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil

Base Information

Chemical Name:6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil
CAS No.:261705-84-4
Molecular Formula:C₁₈H₁₇BrN₄O₄
Molecular Weight:433.261
Hs Code.:

Synonyms:6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil

Suppliers and Price of 6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil

Chemical Property:

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Technology Process of 6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil

There total 1 articles about 6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 199680-59-6
6-amino-5-(3-bromocinnamoylamino)-3-propargyluracil

: 540-51-2
2-bromoethanol

: 261705-84-4
6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 24h;
DOI:10.1021/jm9911480

Reference yield: 57.0%

: 261705-84-4
6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil

: 261705-89-9
8-(m-bromostyryl)-3-(2-hydroxyethyl)-1-propargylxanthine

Guidance literature:: With sodium hydroxide; In methanol; at 50 - 60 ℃;
DOI:10.1021/jm9911480

Reference yield:

: 261705-84-4
6-amino-1-(2-hydroxyethyl)-5-(m-bromocinnamoylamino)-3-propargyluracil

: 8-[(E)-2-(3-Bromo-phenyl)-vinyl]-3-(2-hydroxy-ethyl)-7-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / aq. NaOH / methanol / 50 - 60 °C

2: 81 percent / K₂CO₃ / dimethylformamide / 20 °C

With sodium hydroxide; potassium carbonate; In methanol; N,N-dimethyl-formamide; 1: Cyclization / 2: Methylation;
DOI:10.1021/jm9911480