(2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine

Base Information

Chemical Name:(2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine
CAS No.:1187832-28-5
Molecular Formula:C₂₀H₃₄N₂O
Molecular Weight:318.503
Hs Code.:

Synonyms:(2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine

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Chemical Property of (2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine

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Technology Process of (2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine

There total 3 articles about (2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: C₂₅H₄₂N₂O₃

: 1187832-28-5
(2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine

Guidance literature:: C₂₅H₄₂N₂O₃; With borane; In tetrahydrofuran; for 3h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; for 2h; Reflux;

Reference yield:

: 1016162-91-6
tert-butyl [(1S)-1-{[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]carbonyl}-2-methylpentyl]carbamate

: 1187832-28-5
(2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine

Guidance literature:: tert-butyl [(1S)-1-{[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]carbonyl}-2-methylpentyl]carbamate; With borane; In tetrahydrofuran; for 1.5h; Heating;

With hydrogenchloride; In tetrahydrofuran; for 1.5h; Further stages.; Heating;
DOI:10.1021/jm701344b

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 149655-33-4
(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine

: 1187832-28-5
(2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 2 h / 0 °C

2.1: borane-THF / tetrahydrofuran / 3 h / Reflux

2.2: 2 h / 20 °C / Reflux

With borane-THF; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; acetonitrile;