3-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]propanenitrile

Base Information

Chemical Name:3-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]propanenitrile
CAS No.:1229245-63-9
Molecular Formula:C₁₆H₂₃Cl₂NOSi
Molecular Weight:344.356
Hs Code.:

Synonyms:3-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]propanenitrile

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Chemical Property of 3-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]propanenitrile

Chemical Property:

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Technology Process of 3-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]propanenitrile

There total 7 articles about 3-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: potassium cyanide

: 1229245-64-0
2-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]ethyl methanesulfonate

: 1229245-63-9
3-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]propanenitrile

Guidance literature:: In dimethyl sulfoxide; at 80 ℃; for 4h;

Reference yield:

: 1229246-37-0
5-bromo-2,3-dichlorobenzaldehyde

: 1229245-63-9
3-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]propanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.75 h / 0 °C

2.1: 1H-imidazole / 16 h / 20 °C

3.1: sodium carbonate; triphenylphosphine / palladium diacetate / propan-1-ol; N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere of nitrogen

4.1: 1,4-di(diphenylphosphino)-butane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / bis(1,5-cyclooctadiene)diiridium(I) dichloride / tetrahydrofuran / 16 h / 20 °C

4.2: 8 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / 0 - 20 °C

6.1: dimethyl sulfoxide / 4 h / 80 °C

With 1H-imidazole; sodium tetrahydroborate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,4-di(diphenylphosphino)-butane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; bis(1,5-cyclooctadiene)diiridium(I) dichloride; palladium diacetate; In tetrahydrofuran; methanol; propan-1-ol; dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;

Reference yield:

: 1229245-68-4
(5-bromo-2,3-dichlorophenyl)methanol

: 1229245-63-9
3-[3,4-dichloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)phenyl]propanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / 16 h / 20 °C

2.1: sodium carbonate; triphenylphosphine / palladium diacetate / propan-1-ol; N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere of nitrogen

3.1: 1,4-di(diphenylphosphino)-butane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / bis(1,5-cyclooctadiene)diiridium(I) dichloride / tetrahydrofuran / 16 h / 20 °C

3.2: 8 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 0 - 20 °C

5.1: dimethyl sulfoxide / 4 h / 80 °C

With 1H-imidazole; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,4-di(diphenylphosphino)-butane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; bis(1,5-cyclooctadiene)diiridium(I) dichloride; palladium diacetate; In tetrahydrofuran; propan-1-ol; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;