(8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one

Base Information

• Chemical Name: (8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one
• CAS No.: 1189570-01-1
• Molecular Formula: C₁₇H₂₂F₂N₂O₂
• Molecular Weight: 324.371

Synonyms:(8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one

Chemical Property of (8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one

Chemical Property:

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Technology Process of (8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one

There total 2 articles about (8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetic acid (1189570-02-2) → (8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one (1189570-01-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.666667h;

Reference yield:

[(8R)-6-(tert-butoxycarbonyl)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetic acid (957123-65-8) → (8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one (1189570-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 24 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.67 h / 0 °C

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran;

Reference yield:

(8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one (1189570-01-1) + (2R)-5-sulfanyl-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2',3-b]pyridin]-2'(1'H)-one (1189570-05-5) → (2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one (1189570-37-3)

Guidance literature:

With tributylphosphine; di-tert-butyl-diazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

upstream raw materials:

[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetic acid

[(8R)-6-(tert-butoxycarbonyl)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetic acid

Downstream raw materials:

(2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

(2R)-5-({2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

(2R)-5-({2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfinyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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