(2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Base Information

Chemical Name:(2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
CAS No.:1189570-37-3
Molecular Formula:C₃₈H₄₆F₂N₄O₃SSi
Molecular Weight:704.957
Hs Code.:

(2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Synonyms:(2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Chemical Property of (2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Technology Process of (2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

There total 19 articles about (2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189570-01-1
(8R)-8-(3,5-difluorophenyl)-9-(2-hydroxyethyl)-8-methyl-6,9-diazaspiro[4,5]decan-10-one

: 1189570-05-5
(2R)-5-sulfanyl-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2',3-b]pyridin]-2'(1'H)-one

: 1189570-37-3
(2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: With tributylphosphine; di-tert-butyl-diazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 879132-46-4
1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 1189570-37-3
(2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 13 steps

1.1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

2.1: water

3.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

4.1: caesium carbonate / N,N-dimethyl-formamide / 18 h

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 760.05 Torr

6.1: chloroform / 17 h / Reflux

7.1: hydrogenchloride / methanol

8.1: ethylenediamine; sodium hydroxide / methanol / 0.5 h / pH 10

9.1: hydrogenchloride; sodium nitrite / tetrahydrofuran; methanol; water / 0.27 - 0.28 h / 0 °C

10.1: tetrahydrofuran; methanol; water / 1 h / 65 °C

11.1: sodium hydride / mineral iol; N,N-dimethyl-formamide / 0.25 h

11.2: 1.5 h

12.1: sodium hydroxide / ethanol / 1.5 h / 60 °C

13.1: tributylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

With hydrogenchloride; tributylphosphine; di-tert-butyl-diazodicarboxylate; water; hydrogen; pyridinium hydrobromide perbromide; sodium hydride; ammonium chloride; caesium carbonate; ethylenediamine; sodium hydroxide; zinc; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; mineral iol; water; N,N-dimethyl-formamide;

Reference yield:

: 271-63-6
7-Azaindole

: 1189570-37-3
(2R)-5-({2-[(8R)-8-(3-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]ethyl}sulfanyl)-1'-{[2-(trimethylsiryl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 14 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.42 h / 0 °C

1.2: 1.25 h / 10 °C

2.1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

3.1: water

4.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

5.1: caesium carbonate / N,N-dimethyl-formamide / 18 h

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 18 h / 760.05 Torr

7.1: chloroform / 17 h / Reflux

8.1: hydrogenchloride / methanol

9.1: ethylenediamine; sodium hydroxide / methanol / 0.5 h / pH 10

10.1: hydrogenchloride; sodium nitrite / tetrahydrofuran; methanol; water / 0.27 - 0.28 h / 0 °C

11.1: tetrahydrofuran; methanol; water / 1 h / 65 °C

12.1: sodium hydride / mineral iol; N,N-dimethyl-formamide / 0.25 h

12.2: 1.5 h

13.1: sodium hydroxide / ethanol / 1.5 h / 60 °C

14.1: tributylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

With hydrogenchloride; tributylphosphine; di-tert-butyl-diazodicarboxylate; water; hydrogen; pyridinium hydrobromide perbromide; sodium hydride; ammonium chloride; caesium carbonate; ethylenediamine; sodium hydroxide; zinc; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; mineral iol; water; N,N-dimethyl-formamide; mineral oil;