N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-nitrobenzenesulfonamide

Base Information

Chemical Name:N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-nitrobenzenesulfonamide
CAS No.:1345822-12-9
Molecular Formula:C₂₀H₂₀N₄O₅S₂
Molecular Weight:460.535
Hs Code.:

Synonyms:N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-nitrobenzenesulfonamide

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Chemical Property of N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-nitrobenzenesulfonamide

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Technology Process of N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-nitrobenzenesulfonamide

There total 3 articles about N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345822-06-1
C₁₄H₁₇N₃OS

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1345822-12-9
N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-nitrobenzenesulfonamide

Guidance literature:: With triethylamine; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2011.09.025

Reference yield:

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 1345822-12-9
N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

3: triethylamine / ethyl acetate; N,N-dimethyl-formamide / 8 h / 20 °C

With triethylamine; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.025

Reference yield:

: 1345822-04-9
C₁₉H₂₅N₃O₃S

: 1345822-12-9
N-((2S,3S)-3-hydroxy-1-phenyl-4-(pyrimidin-2-ylthio)butan-2-yl)-4-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

2: triethylamine / ethyl acetate; N,N-dimethyl-formamide / 8 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.025