5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid

Base Information

• Chemical Name: 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid
• CAS No.: 475264-57-4
• Molecular Formula: C₁₆H₁₃NO₃S₃
• Molecular Weight: 363.482

Synonyms:5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid

Chemical Property of 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid

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Technology Process of 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid

There total 1 articles about 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-methoxybenzyl chloride (824-94-2) + 5-(2-mercapto-1,3-thiazol-4-yl)thiophene-2-carboxylic acid (57797-46-3) → 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid (475264-57-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.7164/antibiotics.55.722

Reference yield:

N,N-dimethylammonium chloride (506-59-2) + 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid (475264-57-4) → 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}-N,N-dimethylthiophene-2-carboxamide (475264-69-8)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In chloroform; at -20 - 20 ℃;

DOI:10.7164/antibiotics.55.722

Reference yield:

sarcosine ethyl ester hydrochloride (52605-49-9) + 5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thiophene-2-carboxylic acid (475264-57-4) → ethyl N-[(5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thien-2-yl)carbonyl]-N-methylglycinate (475264-60-9)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In chloroform; at -20 - 20 ℃;

DOI:10.7164/antibiotics.55.722

upstream raw materials:

p-methoxybenzyl chloride

5-(2-mercapto-1,3-thiazol-4-yl)thiophene-2-carboxylic acid

Downstream raw materials:

5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}-N,N-dimethylthiophene-2-carboxamide

ethyl N-[(5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thien-2-yl)carbonyl]-N-methylglycinate

N-[(5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thien-2-yl)methyl]-N,N-dimethylamine

2-[N-[(5-{2-[(4-methoxybenzyl)thio]-1,3-thiazol-4-yl}thien-2-yl)methyl]-N-methylamino]ethanol

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