[(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amine

Base Information

Chemical Name:[(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amine
CAS No.:87306-91-0
Molecular Formula:C₃₁H₄₃NO₃Si
Molecular Weight:505.773
Hs Code.:

Synonyms:[(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amine

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Chemical Property of [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amine

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Technology Process of [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amine

There total 7 articles about [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 87306-81-8
(1R,2R)-3-Methoxy-2-[(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amino]-1-phenyl-propan-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 87306-91-0
[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amine

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1021/jo00170a036

Reference yield:

: 1521-38-6
2,3-dimethoxybenzoic acid

: 87306-91-0
[(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl chloride / CH₂Cl₂ / 14 h

2: 30 percent NH₄OH

3: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, 22 h; 2.) 1,2-dichloroethane, 24 h, reflux

4: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h

5: 1 M DIBAL / diethyl ether / Ambient temperature

6: tetrahydrofuran / 12 h / Ambient temperature

With ammonium hydroxide; oxalyl dichloride; triethyloxonium fluoroborate; diisobutylaluminium hydride; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja00289a023

Reference yield:

: 1521-39-7
2,3-dimethoxybenzamide

: 87306-91-0
[(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, 22 h; 2.) 1,2-dichloroethane, 24 h, reflux

2: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h

3: 1 M DIBAL / diethyl ether / Ambient temperature

4: tetrahydrofuran / 12 h / Ambient temperature

With triethyloxonium fluoroborate; diisobutylaluminium hydride; magnesium; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00289a023