diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Base Information

Chemical Name:diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate
CAS No.:219591-85-2
Molecular Formula:C₃₀H₃₄F₂N₂O₉
Molecular Weight:604.605
Hs Code.:

Synonyms:diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

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Chemical Property of diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

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Technology Process of diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

There total 10 articles about diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 219591-83-0
4-phenyl chloroformate

: 180841-62-7
diprop-2-enyl N-<(4-phenoxy)carbonyl>-L-glutamate

: 219591-85-2
diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Guidance literature:: With triethylamine; In tetrahydrofuran; for 1.5h;
DOI:10.1021/jm980425k

Reference yield: 7.0%

: 219592-01-5
4-bis(2-fluoroethyl)aminophenyl trimethylsilyl ether

: 180839-08-1
C₂₀H₂₂FNO₈

: 219591-85-2
diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Guidance literature:: In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1021/jm980425k

Reference yield:

: 101582-69-8
4--O-benzylphenol

: 219591-85-2
diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h

2: KF, 18-crown-6 ether / acetonitrile / 48 h / 60 °C

3: 98 percent / trifluoroacetic acid / various solvent(s) / 72 h / Ambient temperature

4: 74.5 percent / Et₃N / CH₂Cl₂

5: 35 percent / Et₃N / tetrahydrofuran / 1.5 h

With dmap; potassium fluoride; 18-crown-6 ether; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm980425k