4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid 2-oxo-2-phenyl-ethyl ester

Base Information

• Chemical Name: 4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid 2-oxo-2-phenyl-ethyl ester
• CAS No.: 196097-63-9
• Molecular Formula: C₅₁H₅₉NO₁₅
• Molecular Weight: 926.027

Synonyms:4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid 2-oxo-2-phenyl-ethyl ester

Chemical Property of 4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid 2-oxo-2-phenyl-ethyl ester

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Technology Process of 4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid 2-oxo-2-phenyl-ethyl ester

There total 3 articles about 4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid 2-oxo-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(E)-17-[N-(9-fluorenylmethoxycarbonyl)-L-alanyloxy]-4,7,10,13-tetraoxa-15-heptadecenoic acid (196097-59-3) + 4-(4-Hydroxymethyl-3-methoxy-phenoxy)-butyric acid 2-oxo-2-phenyl-ethyl ester (196097-57-1) → 4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid 2-oxo-2-phenyl-ethyl ester (196097-63-9)

Guidance literature:

With pyridine; 2,6-Dichlorobenzoyl chloride; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1021/ja971383c

Reference yield:

α-bromoacetophenone (70-11-1) → 4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid 2-oxo-2-phenyl-ethyl ester (196097-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Et₃N / ethyl acetate / 16 h / Ambient temperature

2: 64 percent / Pyr, 2,6-Cl₂-PhCOCl / dimethylformamide / 48 h / Ambient temperature

With pyridine; triethylamine; 2,6-Dichlorobenzoyl chloride; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja971383c

Reference yield:

4-(4-hydroxymethyl-3-methoxyphenoxy)-butyric acid (136849-75-7) → 4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid 2-oxo-2-phenyl-ethyl ester (196097-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Et₃N / ethyl acetate / 16 h / Ambient temperature

2: 64 percent / Pyr, 2,6-Cl₂-PhCOCl / dimethylformamide / 48 h / Ambient temperature

With pyridine; triethylamine; 2,6-Dichlorobenzoyl chloride; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja971383c

upstream raw materials:

(E)-17-[N-(9-fluorenylmethoxycarbonyl)-L-alanyloxy]-4,7,10,13-tetraoxa-15-heptadecenoic acid

4-(4-Hydroxymethyl-3-methoxy-phenoxy)-butyric acid 2-oxo-2-phenyl-ethyl ester

α-bromoacetophenone

4-(4-hydroxymethyl-3-methoxyphenoxy)-butyric acid

Downstream raw materials:

4-[4-(3-{2-[2-(2-{(E)-4-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionyloxy]-but-2-enyloxy}-ethoxy)-ethoxy]-ethoxy}-propionyloxymethyl)-3-methoxy-phenoxy]-butyric acid

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