Technology Process of 3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
There total 7 articles about 3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
diethyl ether; water; N,N-dimethyl-formamide;
Ambient temperature;
DOI:10.1021/jm00116a004
- Guidance literature:
-
Multi-step reaction with 2 steps
1: aq. HCl / acetic acid / 100 °C
2: 50 percent / K2CO3 / dimethylformamide; H2O; diethyl ether / Ambient temperature
With
hydrogenchloride; potassium carbonate;
In
diethyl ether; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00116a004
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 69 percent / glacial acetic acid, bromine / 2 h / Ambient temperature
2: 85 percent / formic acid / 4 h / Heating
3: 1.) n-BuLi, 2.) hexachloroethane / 1.) Et2O, THF, -70 deg C, 10 min, 2.) Et2O, THF, -70 deg C, 5 min
4: 3.1 g / benzene / 3 h / 60 °C
5: aq. HCl / acetic acid / 100 °C
6: 50 percent / K2CO3 / dimethylformamide; H2O; diethyl ether / Ambient temperature
With
hydrogenchloride; n-butyllithium; formic acid; hexachloroethane; bromine; potassium carbonate; acetic acid;
In
diethyl ether; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00116a004
