3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:74115-02-9
Molecular Formula:C₂₁H₂₄ClNO₂
Molecular Weight:357.88
Hs Code.:

Synonyms:3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of 3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 7 articles about 3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 67287-38-1
6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 106-95-6
allyl bromide

: 74115-02-9
3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With potassium carbonate; In diethyl ether; water; N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm00116a004

Reference yield:

: 67287-46-1
6-chloro-7,8-dimethoxy-3-cyano-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 74115-02-9
3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / acetic acid / 100 °C

2: 50 percent / K₂CO₃ / dimethylformamide; H₂O; diethyl ether / Ambient temperature

With hydrogenchloride; potassium carbonate; In diethyl ether; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00116a004

Reference yield:

: 20569-49-7
7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 74115-02-9
3-allyl-6-chloro-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 6 steps

1: 69 percent / glacial acetic acid, bromine / 2 h / Ambient temperature

2: 85 percent / formic acid / 4 h / Heating

3: 1.) n-BuLi, 2.) hexachloroethane / 1.) Et₂O, THF, -70 deg C, 10 min, 2.) Et₂O, THF, -70 deg C, 5 min

4: 3.1 g / benzene / 3 h / 60 °C

5: aq. HCl / acetic acid / 100 °C

6: 50 percent / K₂CO₃ / dimethylformamide; H₂O; diethyl ether / Ambient temperature

With hydrogenchloride; n-butyllithium; formic acid; hexachloroethane; bromine; potassium carbonate; acetic acid; In diethyl ether; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00116a004