2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

Base Information

Chemical Name:2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine
CAS No.:1011528-13-4
Molecular Formula:C₁₇H₁₃FN₈O₂
Molecular Weight:380.341
Hs Code.:

Synonyms:2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

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Chemical Property of 2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

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Technology Process of 2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

There total 5 articles about 2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 408352-74-9
2-chloro-5-nitropyrimidine-4,6-diamine

: 1011527-96-0
3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridine

: 1011528-13-4
2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

Guidance literature:: With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; at 90 ℃; for 4h;

Reference yield:

: 1011527-91-5
1-(3,5-dichloropyridin-2-yl)-2-(2-fluorophenyl)ethanone

: 1011528-13-4
2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate; pyridine / Reflux

2: hydrogen; palladium 10% on activated carbon; triethylamine / ethanol; tetrahydrofuran

3: sodium hydride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With pyridine; hydrazine hydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00449

Reference yield:

: 70151-22-3
methyl 3,5-dichloropicolinic acid chloride

: 1011528-13-4
2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / Inert atmosphere

2: sodium chloride; dimethyl sulfoxide / water / 150 °C / Microwave irradiation

3: hydrazine hydrate; pyridine / Reflux

4: hydrogen; palladium 10% on activated carbon; triethylamine / ethanol; tetrahydrofuran

5: sodium hydride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With pyridine; hydrazine hydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; dimethyl sulfoxide; triethylamine; sodium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00449