70151-22-3

Basic information

• Product Name: 3,5-Dichloropyridine-2-carbonyl chloride
• Synonyms: 3,5-Dichloropyridine-2-carbonyl chloride
• CAS NO: 70151-22-3
• Molecular Formula: C₆H₂Cl₃NO
• Molecular Weight: 210.44518
• Mol File: 70151-22-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,5-Dichloropyridine-2-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloropyridine-2-carbonyl chloride(70151-22-3)
• EPA Substance Registry System: 3,5-Dichloropyridine-2-carbonyl chloride(70151-22-3)

Safety Data

• Hazardous Substances Data: 70151-22-3(Hazardous Substances Data)

Upstream product

• 200711-45-1 3,4,5-trichloro-pyridine-2-carboxylic acid methyl ester 
• 5439-04-3 3,4,5-trichloropicolinic acid 
• 846045-08-7 3,5-dichloro-4-hydroxy-pyridine-2-carboxylic acid 
• 81719-53-1 3,5-dichloropyridine-2-carboxylic acid 

Downstream Products

• 5439-08-7 methyl 3,5-dichloropyridine-2-carboxylate 
• 1011527-92-6 6-chloro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridine 
• 1011527-96-0 3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridine 
• 1011527-91-5 1-(3,5-dichloropyridin-2-yl)-2-(2-fluorophenyl)ethanone 
• 1011527-86-8 methyl {4,6-diamino-2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl} carbamate 
• 1011527-85-7 2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine 
• 1011528-13-4 2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4,6-diamine 
• 1011527-90-4 methyl 3-(3,5-dichloropyridin-2-yl)-2-(2-fluorophenyl)-3-oxopropanoate 

Relevant articles and documents

SGC STIMULATORS

The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an inc

BACE1 INHIBITORS

The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Structural Investigation of the Naphthyridone Scaffold: Identification of a 1,6-Naphthyridone Derivative with Potent and Selective Anti-HIV Activity

Building upon a large, previously reported series of anti-HIV 6-desfluoroquinolones endowed with a peculiar mechanism of action, the inhibition of Tat-mediated transcription, replacement of the quinolone nucleus with a naphthyridone core was shown to be very productive. In this work, the naphthyridone scaffold was investigated in depth by synthesizing various analogues. This led to the identification of NM13 as the most selective derivative obtained in MT-4 cells. It is the result of the successful combination of the 1,6-naphthyridone nucleus and the C7 benzothiazolpiperazine group, which, for the first time, not only grants potent anti-HIV activity but displays very high selectivity. Further studies aimed at a more thorough investigation of the anti-HIV profile of this new derivative are in progress. Best in class: The naphthyridone scaffold was investigated in depth by synthesizing various analogues that were tested for their anti-HIV activity. This led to the identification of a very potent and nontoxic compound, NM13, as the most selective anti-HIV derivative ever obtained in the quinolone class of transcription inhibitors. It is the result of a powerful combination of the 1,6-naphthyridone nucleus and the C7 benzothiazolpiperazine group.