trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid methyl ester

Base Information

Chemical Name:trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid methyl ester
CAS No.:1395921-61-5
Molecular Formula:C₂₂H₃₂N₂O₄
Molecular Weight:388.507
Hs Code.:

Synonyms:trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid methyl ester

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Chemical Property of trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid methyl ester

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Technology Process of trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid methyl ester

There total 7 articles about trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.6%

: trans-4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride

: 79-22-1
methyl chloroformate

: 1395921-61-5
trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1395921-61-5
trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; sodium carbonate / palladium diacetate / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere; Reflux

4.1: dichloromethane; methanol / 2 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; ammonium formate; sodium carbonate; triethylamine; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 6698-13-1
4-bromo-benzo[1,3]dioxole

: 1395921-61-5
trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; sodium carbonate / palladium diacetate / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere; Reflux

4.1: dichloromethane; methanol / 2 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; ammonium formate; sodium carbonate; triethylamine; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane;