trans-5-chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide

Base Information

Chemical Name:trans-5-chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide
CAS No.:1319742-75-0
Molecular Formula:C₂₅H₃₁ClN₄O₂
Molecular Weight:455
Hs Code.:

Synonyms:trans-5-chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide

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Chemical Property of trans-5-chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide

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Technology Process of trans-5-chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide

There total 5 articles about trans-5-chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207529-79-0
((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate

: 77557-03-0
1-isobutyl-1,3-dihydrobenzoimidazol-2-one

: 1319742-75-0
trans-5-chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide

Guidance literature:: 1-isobutyl-1,3-dihydrobenzoimidazol-2-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 75 ℃; for 3.5h;

Reference yield:

: 1092286-30-0
5-chloro-2-methyl-3-pyridinecarboxylic acid

: 1319742-75-0
trans-5-chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C / Inert atmosphere

5.2: 3.5 h / 75 °C

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1207529-88-1
5-chloro-2-methylnicotinoyl chloride

: 1319742-75-0
trans-5-chloro-N-[4-(3-isobutyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexyl]-2-methyl-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C / Inert atmosphere

4.2: 3.5 h / 75 °C

With pyridine; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;