((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate

Base Information

Chemical Name:((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate
CAS No.:1207529-79-0
Molecular Formula:C₁₅H₂₁ClN₂O₄S
Molecular Weight:360.862
Hs Code.:

Synonyms:((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate

Chemical Property:

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Technology Process of ((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate

There total 4 articles about ((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1207529-78-9
5-chloro-N-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-2-methylnicotinamide

: 7143-01-3
Methanesulfonic anhydride

: 1207529-79-0
((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate

Guidance literature:: With triethylamine; In tetrahydrofuran; dichloromethane; at 18 - 25 ℃; for 20.5h;

Reference yield:

: 1207529-78-9
5-chloro-N-((1r,4r)-4-(hydroxymethyl)cyclohexyl)-2-methylnicotinamide

: 124-63-0
methanesulfonyl chloride

: 1207529-79-0
((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1092286-30-0
5-chloro-2-methyl-3-pyridinecarboxylic acid

: 1207529-79-0
((1r,4r)-4-(5-chloro-2-methylnicotinamido)cyclohexyl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4: pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;