di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate
CAS No.:129780-82-1
Molecular Formula:C₂₈H₃₇N₇O₅
Molecular Weight:551.646
Hs Code.:

Synonyms:di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate

Chemical Property:

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Technology Process of di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate

There total 3 articles about di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10541-83-0,937737-33-2
N-methyl-p-aminobenzoic acid

: 129780-82-1
di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / i-Pr₂NEt / dimethylformamide / 1.5 h / Ambient temperature

2: 89 percent / 2-ethoxy-ethanol / 1 h / 135 °C

3: 1.) diethyl phosphorocyanidate, Et₃N / 1.) DMF, RT, 20 min

With diethyl cyanophosphonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 2-ethoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00105a036

Reference yield:

: 40127-91-1
2-Amino-5-chloromethylpyrazine-3-carbonitrile

: 129780-82-1
di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / i-Pr₂NEt / dimethylformamide / 1.5 h / Ambient temperature

2: 89 percent / 2-ethoxy-ethanol / 1 h / 135 °C

3: 1.) diethyl phosphorocyanidate, Et₃N / 1.) DMF, RT, 20 min

With diethyl cyanophosphonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 2-ethoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00105a036

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 129780-81-0
4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoic acid

: 129780-82-1
di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>methylamino>benzoyl>-L-glutamate

Guidance literature:: With diethyl cyanophosphonate; triethylamine; Yield given. Multistep reaction; 1.) DMF, RT, 20 min;
DOI:10.1021/jm00105a036