ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

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Chemical Name:ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate
CAS No.:1224848-86-5
Molecular Formula:C₃₇H₃₈N₄O₄
Molecular Weight:602.733
Hs Code.:

Synonyms:ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

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Chemical Property of ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

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Technology Process of ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

There total 11 articles about ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1224848-85-4
ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate

: 1224848-86-5
ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 60 ℃; for 3h;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1224848-86-5
ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 h / 20 °C / Cooling with ice

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1 h

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1 h / -78 °C

4.1: 1H-imidazole / chloroform / 20 h / 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 70 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 60 °C

With 1H-imidazole; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; lithium diisopropyl amide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; n-heptane; chloroform; ethylbenzene; N,N-dimethyl-formamide;

Reference yield:

: 1224847-65-7
ethyl 4,5-dihydroimidazo[1,5-a]quinoline-3-carboxylate

: 1224848-86-5
ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

2.1: manganese(IV) oxide / chloroform / 15 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1 h / -78 °C

4.1: 1H-imidazole / chloroform / 20 h / 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 70 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 60 °C

With 1H-imidazole; manganese(IV) oxide; lithium aluminium tetrahydride; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;