ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate

Base Information

Chemical Name:ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate
CAS No.:1224848-85-4
Molecular Formula:C₃₇H₃₆N₄O₄
Molecular Weight:600.717
Hs Code.:

Synonyms:ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate

There total 10 articles about ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1224848-84-3
ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

: 1224848-85-4
ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 70 ℃; for 6h;

Reference yield:

: 553-03-7
3,4-dihydro-2(1H)-quinolone

: 1224848-85-4
ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Cooling with ice

1.2: 1 h / -30 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

3.1: manganese(IV) oxide / chloroform / 15 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1 h / -78 °C

5.1: 1H-imidazole / chloroform / 20 h / 20 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 70 °C

With 1H-imidazole; manganese(IV) oxide; lithium aluminium tetrahydride; potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1224847-65-7
ethyl 4,5-dihydroimidazo[1,5-a]quinoline-3-carboxylate

: 1224848-85-4
ethyl (2Z)-2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-2-propenoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

2.1: manganese(IV) oxide / chloroform / 15 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1 h / -78 °C

4.1: 1H-imidazole / chloroform / 20 h / 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 70 °C

With 1H-imidazole; manganese(IV) oxide; lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;