5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid

Base Information

Chemical Name:5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid
CAS No.:1394374-53-8
Molecular Formula:C₁₉H₁₇NO₅S₂
Molecular Weight:403.48
Hs Code.:

Synonyms:5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid

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Chemical Property of 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid

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Technology Process of 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid

There total 5 articles about 5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 203195-42-0
methyl 3-bromo-4-methylthiophene-2-carboxylate

: 5720-07-0
4-methoxyphenylboronic acid

: 613660-87-0
4-sulfamoylphenylboronic acid

: 1394374-53-8
5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid

Guidance literature:: methyl 3-bromo-4-methylthiophene-2-carboxylate; 4-sulfamoylphenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 105 ℃; for 15h; Inert atmosphere; Sealed tube;

With bromine; In dichloromethane; at 0 - 25 ℃; for 2h; Inert atmosphere;

4-methoxyphenylboronic acid; Further stages;
DOI:10.1021/acs.jmedchem.9b01569

Reference yield:

: 85006-31-1
3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

: 1394374-53-8
5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 4 h / 20 - 25 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 15 h / 25 - 105 °C / Inert atmosphere; Sealed tube

3: bromine / dichloromethane / 2 h / 0 - 25 °C

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 1 h / 25 - 100 °C / Inert atmosphere

5: sodium hydroxide; water / ethanol / 2 h / 25 - 55 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; water; bromine; potassium carbonate; sodium hydroxide; copper(ll) bromide; In ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 203195-42-0
methyl 3-bromo-4-methylthiophene-2-carboxylate

: 1394374-53-8
5-(4-methoxyphenyl)-4-methyl-3-(4-sulfamoylphenyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 15 h / 25 - 105 °C / Inert atmosphere; Sealed tube

2: bromine / dichloromethane / 2 h / 0 - 25 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 1 h / 25 - 100 °C / Inert atmosphere

4: sodium hydroxide; water / ethanol / 2 h / 25 - 55 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; bromine; potassium carbonate; sodium hydroxide; In ethanol; dichloromethane; toluene;