2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one

Base Information

• Chemical Name: 2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one
• CAS No.: 266684-42-8
• Molecular Formula: C₂₅H₃₁N₅O₄Si
• Molecular Weight: 493.638

Synonyms:2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one

Chemical Property of 2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one

Chemical Property:

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Technology Process of 2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one

There total 3 articles about 2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester (266684-41-7) → 2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one (266684-42-8)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 0.266667h;

DOI:10.1016/S0040-4039(99)02280-7

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one (266684-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 24 h / 20 °C

2: 85 percent / NaOMe / methanol / 0.27 h / 20 °C

With 1H-imidazole; sodium methylate; In methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis;

DOI:10.1016/S0040-4039(99)02280-7

Reference yield:

ganciclovir monopropionate (194159-18-7) → 2-amino-9-[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-ethoxymethyl]-1,9-dihydro-purin-6-one (266684-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 24 h / 20 °C

2: 85 percent / NaOMe / methanol / 0.27 h / 20 °C

With 1H-imidazole; sodium methylate; In methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis;

DOI:10.1016/S0040-4039(99)02280-7

upstream raw materials:

propionic acid 2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester

tert-butylchlorodiphenylsilane

ganciclovir monopropionate

Downstream raw materials:

Isobutyric acid 3-(tert-butyl-diphenyl-silanyloxy)-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propyl ester

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