3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-N,N-diethylacrylamide

Base Information

Chemical Name:3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-N,N-diethylacrylamide
CAS No.:891188-87-7
Molecular Formula:C₂₀H₃₃NO₃Si
Molecular Weight:363.572
Hs Code.:

Synonyms:3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-N,N-diethylacrylamide

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Chemical Property of 3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-N,N-diethylacrylamide

Chemical Property:

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Technology Process of 3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-N,N-diethylacrylamide

There total 2 articles about 3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-N,N-diethylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 891188-86-6
(E)-N,N-diethyl-3-(3-hydroxy-4-methoxyphenyl)acrylamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 891188-87-7
3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-N,N-diethylacrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2006.02.001

Reference yield:

: 537-73-5
trans-3-hydroxy-4-methoxycinnamic acid

: 891188-87-7
3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-N,N-diethylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 3 h / 20 °C

2: 65 percent / ethyldiisopropylamine / tetrahydrofuran / 24 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.02.001

Reference yield:

: 891188-87-7
3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-N,N-diethylacrylamide

: trans-N,N-diethyl-4-(3-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 6 percent / triethylamine; NaOCl / CH₂Cl₂; H₂O / 25 h / 0 - 20 °C

2: 83 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With sodium hypochlorite; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2006.02.001