4-[3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)ureido]piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)ureido]piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1418025-47-4
Molecular Formula:C₂₇H₃₁ClN₄O₄
Molecular Weight:511.021
Hs Code.:

Synonyms:4-[3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)ureido]piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)ureido]piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)ureido]piperidine-1-carboxylic acid tert-butyl ester

There total 10 articles about 4-[3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)ureido]piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1418026-14-8
(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)carbamic acid 4-nitro-phenyl ester

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1418025-47-4
4-[3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)ureido]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418025-47-4
4-[3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)ureido]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

5.1: platinum(IV) oxide; hydrogen / ethyl acetate / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

With platinum(IV) oxide; N-Bromosuccinimide; sodium azide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418025-47-4
4-[3-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)ureido]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

1.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

4.1: platinum(IV) oxide; hydrogen / ethyl acetate / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

With platinum(IV) oxide; N-Bromosuccinimide; sodium azide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;