2-<3,3-bis(trifluoromethyl)-3H-1,2-benziodoxol-1-yl>-α,α-bis(trifluoromethyl)benzenemethanol

Base Information

• Chemical Name: 2-<3,3-bis(trifluoromethyl)-3H-1,2-benziodoxol-1-yl>-α,α-bis(trifluoromethyl)benzenemethanol
• CAS No.: 147492-24-8
• Molecular Formula: C₁₈H₉F₁₂IO₂
• Molecular Weight: 612.154

Synonyms:2-<3,3-bis(trifluoromethyl)-3H-1,2-benziodoxol-1-yl>-α,α-bis(trifluoromethyl)benzenemethanol

Chemical Property of 2-<3,3-bis(trifluoromethyl)-3H-1,2-benziodoxol-1-yl>-α,α-bis(trifluoromethyl)benzenemethanol

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Technology Process of 2-<3,3-bis(trifluoromethyl)-3H-1,2-benziodoxol-1-yl>-α,α-bis(trifluoromethyl)benzenemethanol

There total 5 articles about 2-<3,3-bis(trifluoromethyl)-3H-1,2-benziodoxol-1-yl>-α,α-bis(trifluoromethyl)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

bis<α,α-bis(trifluoromethyl)benzenemethanolato(2-)-C2,Oα>bromoiodine (80540-69-8) → 2-<3,3-bis(trifluoromethyl)-3H-1,2-benziodoxol-1-yl>-α,α-bis(trifluoromethyl)benzenemethanol (147492-24-8)

Guidance literature:

In acetonitrile; for 0.333333h; Heating;

DOI:10.1021/ja00059a052

Reference yield: 35.0%

bis<α,α-bis(trifluoromethyl)benzenemethanolato(2-)-C2,Oα>bromoiodine (80540-69-8) + trifluoroacetic acid (76-05-1) → 2-<3,3-bis(trifluoromethyl)-3H-1,2-benziodoxol-1-yl>-α,α-bis(trifluoromethyl)benzenemethanol (147492-24-8) + bis<α,α-bis(trifluoromethyl)benzenemethanolato(2-)-C2,Oα>iodine(1+) trifluoroacetate

Guidance literature:

In water; Heating;

DOI:10.1021/ja00059a052

Reference yield:

lithium 1,1,1,3,3,3-hexafluoro-2-(2-lithiophenyl)-2-propoxide (70091-67-7) → 2-<3,3-bis(trifluoromethyl)-3H-1,2-benziodoxol-1-yl>-α,α-bis(trifluoromethyl)benzenemethanol (147492-24-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) tetramethylethylenediamine, 2.) aq. HCl, 3.) aq. KOH

2: 92 percent / Br₂ / CH₂Cl₂

3: 81 percent / acetonitrile / 0.33 h / Heating

With hydrogenchloride; potassium hydroxide; N,N,N,N,-tetramethylethylenediamine; bromine; In dichloromethane; acetonitrile;

DOI:10.1021/ja00059a052

upstream raw materials:

bis<α,α-bis(trifluoromethyl)benzenemethanolato(2-)-C₂,O_α>bromoiodine

trifluoroacetic acid

lithium 1,1,1,3,3,3-hexafluoro-2-(2-lithiophenyl)-2-propoxide

1-chloro-3,3-bis(trifluoromethyl)-1,3-dihydro-1λ³-benzo[d][1,2]iodaoxole

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