2-Naphthalenecarboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]- (9CI)

Base Information

• Chemical Name: 2-Naphthalenecarboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]- (9CI)
• CAS No.: 197075-93-7
• Molecular Formula: C₁₉H₁₆N₄O₃
• Molecular Weight: 348.361
• Mol file: 197075-93-7.mol

Synonyms:2-Naphthalenecarboxamide,N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]-(9CI)

Chemical Property of 2-Naphthalenecarboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]- (9CI)

Chemical Property:

• PSA: 99.12000
• LogP: 1.82210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Naphthalenecarboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]- (9CI)

There total 3 articles about 2-Naphthalenecarboxamide, N-[6-amino-1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(2-propynyl)-5-pyrimidinyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Naphthalene-2-carboxylic acid (6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide (197075-92-6) + methyl iodide (74-88-4) → Naphthalene-2-carboxylic acid (6-amino-1-methyl-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide (197075-93-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1016/S0223-5234(97)88913-1

Reference yield:

5,6-diamino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione (146830-75-3) → Naphthalene-2-carboxylic acid (6-amino-1-methyl-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide (197075-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / pyridine / Ambient temperature

2: 75 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(97)88913-1

Reference yield:

2-naphthaloyl chloride (2243-83-6) → Naphthalene-2-carboxylic acid (6-amino-1-methyl-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide (197075-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / pyridine / Ambient temperature

2: 75 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(97)88913-1

upstream raw materials:

Naphthalene-2-carboxylic acid (6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

methyl iodide

5,6-diamino-3-prop-2-ynyl-1H,3H-pyrimidine-2,4-dione

2-naphthaloyl chloride

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