C₁₀H₈FNO

Base Information

• Chemical Name: C₁₀H₈FNO
• CAS No.: 1419181-94-4
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177.178
• Mol file: 1419181-94-4.mol

Synonyms:C₁₀H₈FNO

Chemical Property of C₁₀H₈FNO

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₁₀H₈FNO

There total 1 articles about C₁₀H₈FNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoro-2-methyl-2,3-dihydro-1H-inden-1-one O-acetyl oxime → C10H8FNO (1419181-94-4)

Guidance literature:

With copper(l) iodide; In dimethyl sulfoxide; at 90 ℃; for 12h;

DOI:10.1021/acs.joc.8b02103

Reference yield: 73.0%

C10H8FNO (1419181-94-4) + methyl iodide (74-88-4) → 4-fluoro-2-(3-oxobutan-2-yl)benzonitrile (1447698-29-4)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In dichloromethane; at 40 ℃; for 2h;

DOI:10.1021/ol401606x

Reference yield:

C10H8FNO (1419181-94-4) → 2-(3-hydroxybutan-2-yl)-4-fluorobenzonitrile

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 2 h / 40 °C

2: NADH; triethylamine / isopropyl alcohol; hexane / 72 h / 30 °C / pH 7.5 / Enzymatic reaction

With tetra(n-butyl)ammonium hydrogensulfate; triethylamine; NADH; sodium hydroxide; In hexane; dichloromethane; isopropyl alcohol;

DOI:10.1021/ol401606x

Downstream raw materials:

4-fluoro-2-(3-oxobutan-2-yl)benzonitrile

Refernces