1-Phenoxy-4-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-butan-2-ol

Base Information

Chemical Name:1-Phenoxy-4-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-butan-2-ol
CAS No.:221302-44-9
Molecular Formula:C₂₇H₄₂O₄
Molecular Weight:430.628
Hs Code.:

Synonyms:1-Phenoxy-4-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-butan-2-ol

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Chemical Property of 1-Phenoxy-4-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-butan-2-ol

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Technology Process of 1-Phenoxy-4-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-butan-2-ol

There total 13 articles about 1-Phenoxy-4-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 221302-30-3
tert-Butyl-{1-phenoxymethyl-3-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-propoxy}-diphenyl-silane

: 221302-44-9
1-Phenoxy-4-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-butan-2-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 16h; Ambient temperature;
DOI:10.1021/jo981897+

Reference yield:

: 42599-17-7
(E)-1-iodo-1-octene

: 221302-44-9
1-Phenoxy-4-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-butan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaOEt, 2.) aq. NaOH, aq. h2O₂ / 1.) Pd(PPh₃)4 / 1.) C₆H₆, EtOH, reflux, 2 h, 2.) room temperature

2: 95 percent / PPh₃, imidazole, I₂ / CH₂Cl₂ / 0.67 h / Heating

3: 1.) nBuLi / 1.) THF, hexane, room temperature, 45 min, 2.) THF, room temperature, 16 h

4: 86 percent / NH₄OAc, aq. TiCl₃ / dioxane; aq. acetic acid / 0.33 h / Ambient temperature

5: 92 percent / imidazole / CH₂Cl₂ / 16 h

6: 97 percent / pTsOH / benzene / 16 h / Heating

7: 99 percent / TBAF / tetrahydrofuran / 16 h

With 1H-imidazole; sodium hydroxide; n-butyllithium; titanium(III) chloride; ammonium acetate; tetrabutyl ammonium fluoride; dihydrogen peroxide; iodine; sodium ethanolate; toluene-4-sulfonic acid; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; benzene;
DOI:10.1021/jo990266s

Reference yield:

: 132048-17-0
(E)-(5-hydroxypent-1-en-1-yl)boronic acid

: 221302-44-9
1-Phenoxy-4-[((5E,7E)-2-tetradeca-5,7-dienyl)-[1,3]dioxolan-2-yl]-butan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaOEt, 2.) aq. NaOH, aq. h2O₂ / 1.) Pd(PPh₃)4 / 1.) C₆H₆, EtOH, reflux, 2 h, 2.) room temperature

2: 95 percent / PPh₃, imidazole, I₂ / CH₂Cl₂ / 0.67 h / Heating

3: 1.) nBuLi / 1.) THF, hexane, room temperature, 45 min, 2.) THF, room temperature, 16 h

4: 86 percent / NH₄OAc, aq. TiCl₃ / dioxane; aq. acetic acid / 0.33 h / Ambient temperature

5: 92 percent / imidazole / CH₂Cl₂ / 16 h

6: 97 percent / pTsOH / benzene / 16 h / Heating

7: 99 percent / TBAF / tetrahydrofuran / 16 h

With 1H-imidazole; sodium hydroxide; n-butyllithium; titanium(III) chloride; ammonium acetate; tetrabutyl ammonium fluoride; dihydrogen peroxide; iodine; sodium ethanolate; toluene-4-sulfonic acid; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; benzene;
DOI:10.1021/jo990266s