4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid

Base Information

Chemical Name:4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid
CAS No.:852221-24-0
Molecular Formula:C₃₁H₂₉N₅O₃
Molecular Weight:519.603
Hs Code.:

Synonyms:4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid

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Chemical Property of 4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid

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Technology Process of 4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid

There total 12 articles about 4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852221-26-2
4-{6-[3-(4-tert-butyl-benzoylamino)-2-methylphenyl]-imidazo[1,2-a]pyrazin-8-ylamino}-benzoic acid ethyl ester

: 852221-24-0
4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid

Guidance literature:: With sodium hydroxide; water; In ethanol; for 1h; Heating / reflux;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 852221-24-0
4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

2: hydrogen; palladium on activated charcoal / ethanol / 6 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 40 h / 20 °C / Inert atmosphere

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 6 h / 95 °C / Inert atmosphere; Sealed tube

5: sodium hydroxide; water / ethanol / 1 h / Inert atmosphere; Reflux

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; water; hydrogen; potassium acetate; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; 4: |Suzuki Coupling;
DOI:10.1021/jm500305p

Reference yield:

: 886854-79-1
3-(5,5-dimethyl[1,3,2]dioxaborinan-2-yl)-2-methylaniline

: 852221-24-0
4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0.25 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 95 °C

3: sodium hydroxide; water / ethanol / 1 h / Heating / reflux

With sodium hydroxide; water; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water;