4-tert-butyl-N-(2-methyl-3-{8-[4-(morpholine-4-carbonyl)phenylamino]imidazo[1,2-a]pyrazin-6-yl}phenyl)benzamide

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Chemical Name:4-tert-butyl-N-(2-methyl-3-{8-[4-(morpholine-4-carbonyl)phenylamino]imidazo[1,2-a]pyrazin-6-yl}phenyl)benzamide
CAS No.:886854-77-9
Molecular Formula:C₃₅H₃₆N₆O₃
Molecular Weight:588.709
Hs Code.:

Synonyms:4-tert-butyl-N-(2-methyl-3-{8-[4-(morpholine-4-carbonyl)phenylamino]imidazo[1,2-a]pyrazin-6-yl}phenyl)benzamide

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Chemical Property of 4-tert-butyl-N-(2-methyl-3-{8-[4-(morpholine-4-carbonyl)phenylamino]imidazo[1,2-a]pyrazin-6-yl}phenyl)benzamide

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Technology Process of 4-tert-butyl-N-(2-methyl-3-{8-[4-(morpholine-4-carbonyl)phenylamino]imidazo[1,2-a]pyrazin-6-yl}phenyl)benzamide

There total 12 articles about 4-tert-butyl-N-(2-methyl-3-{8-[4-(morpholine-4-carbonyl)phenylamino]imidazo[1,2-a]pyrazin-6-yl}phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 852221-24-0
4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid

: 886854-77-9
4-tert-butyl-N-(2-methyl-3-{8-[4-(morpholine-4-carbonyl)phenylamino]imidazo[1,2-a]pyrazin-6-yl}phenyl)benzamide

Guidance literature:: 4-{6-[3-(4-tert-butylbenzoylamino)-2-methylphenyl]imidazo[1,2-a]pyrazin-8-ylamino}benzoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h; Inert atmosphere;

morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm500305p

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 886854-77-9
4-tert-butyl-N-(2-methyl-3-{8-[4-(morpholine-4-carbonyl)phenylamino]imidazo[1,2-a]pyrazin-6-yl}phenyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

2.1: hydrogen; palladium on activated charcoal / ethanol / 6 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 40 h / 20 °C / Inert atmosphere

4.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 6 h / 95 °C / Inert atmosphere; Sealed tube

5.1: sodium hydroxide; water / ethanol / 1 h / Inert atmosphere; Reflux

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

6.2: 2 h / 20 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; potassium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 4.1: |Suzuki Coupling;
DOI:10.1021/jm500305p

Reference yield:

: 886854-78-0
2-(2-methyl-3-nitrophenyl)-5,5-dimethyl[1,3,2]dioxaborinane

: 886854-77-9
4-tert-butyl-N-(2-methyl-3-{8-[4-(morpholine-4-carbonyl)phenylamino]imidazo[1,2-a]pyrazin-6-yl}phenyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h / 20 °C / 2068.65 Torr

2.1: triethylamine / tetrahydrofuran / 0.25 h / 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / 95 °C

4.1: sodium hydroxide; water / ethanol / 1 h / Heating / reflux

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C

5.2: 2 h / 20 °C

With sodium hydroxide; water; hydrogen; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;