1-{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}ethanol

Base Information

Chemical Name:1-{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}ethanol
CAS No.:1187821-91-5
Molecular Formula:C₂₁H₁₆ClFN₂O
Molecular Weight:366.822
Hs Code.:

Synonyms:1-{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}ethanol

Chemical Property:

Purity/Quality:

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Technology Process of 1-{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}ethanol

There total 3 articles about 1-{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187822-16-7
3-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorobenzaldehyde

: 75-16-1
methylmagnesium bromide

: 1187821-91-5
1-{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}ethanol

Guidance literature:: 3-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorobenzaldehyde; methylmagnesium bromide; In tetrahydrofuran; dibutyl ether; at 0 ℃; for 1h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; dibutyl ether;

Reference yield:

: 452967-47-4
6-bromo-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

: 1187821-91-5
1-{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; acetonitrile / 21 h / 70 °C / Inert atmosphere

2: tetrahydrofuran; dibutyl ether / 1 h / 0 °C / Inert atmosphere

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dibutyl ether; water; toluene; acetonitrile;

Reference yield:

: 536-38-9
4-chlorobenzoylmethyl bromide

: 1187821-91-5
1-{3-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorophenyl}ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / propan-1-ol / 16 h / 80 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; acetonitrile / 21 h / 70 °C / Inert atmosphere

3: tetrahydrofuran; dibutyl ether / 1 h / 0 °C / Inert atmosphere

With sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; propan-1-ol; dibutyl ether; water; toluene; acetonitrile;