(±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate

Base Information

Chemical Name:(±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate
CAS No.:1431884-98-8
Molecular Formula:C₂₅H₂₆N₂O₅
Molecular Weight:434.492
Hs Code.:

Synonyms:(±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate

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Chemical Property of (±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate

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Technology Process of (±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate

There total 3 articles about (±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 40149-83-5
2-(2-iodoethyl)isoindoline-1,3-dione

: 1410940-49-6
3-methylbut-2-en-1-yl 3-(methyl(phenyl)amino)-3-oxopropanoate

: 1431884-98-8
(±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate

Guidance literature:: 3-methylbut-2-en-1-yl 3-(methyl(phenyl)amino)-3-oxopropanoate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

2-(2-iodoethyl)isoindoline-1,3-dione; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/ol400899e

Reference yield:

: 1334485-21-0
3-(3-methyl-2-buten-1-yl)malonate

: 1431884-98-8
(±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexyl-carbodiimide; triethylamine / tetrahydrofuran / 0.33 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 1.5 h / 20 °C / Inert atmosphere

With sodium hydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol400899e

Reference yield:

: 556-82-1
3-methyl-2-buten-1-ol

: 1431884-98-8
(±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 110 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide; triethylamine / tetrahydrofuran / 0.33 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

3.2: 1.5 h / 20 °C / Inert atmosphere

With sodium hydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol400899e