40149-83-5

Usage

Uses

Used in Organic Synthesis:
2-(2-iodoethyl)isoindoline-1,3-dione is utilized as a building block in organic synthesis for the creation of various pharmacologically active compounds. Its structural features make it a valuable component in the development of new molecules with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(2-iodoethyl)isoindoline-1,3-dione is employed as a key intermediate in the synthesis of drug candidates. Its unique properties allow for the exploration of its potential biological activities and its integration into novel therapeutic agents.
Used in Radiochemical Applications:
The presence of the iodine atom in 2-(2-iodoethyl)isoindoline-1,3-dione makes it suitable for use in radiochemical applications. It can be incorporated into compounds for use in radiopharmaceutical development, where it may enhance imaging and diagnostic capabilities in medical settings.
Used in Labeling and Tracing Experiments:
2-(2-iodoethyl)isoindoline-1,3-dione is also used for labeling and tracing experiments in chemical and biological research. Its iodine atom can be substituted with radioactive isotopes, facilitating the tracking of molecular interactions and the study of biochemical pathways.

Upstream product

• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 5460-83-3 2-(1,3-dioxoisoindolin-2-yl)ethyl 4-methylbenzenesulfonate 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 85-44-9 phthalic anhydride 
• 128648-56-6 2-(1,3-dioxoisoindolin-2-yl)ethyl methanesulfonate 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 6418-95-7 1-Stearoyl-2-oleoyl-phosphatidylethanolamin 
• 329710-82-9 N-[2-(trifluoromethoxy)ethyl]phthalimide 
• 1108732-97-3 C₂₈H₂₃NO₂P⁽¹⁺⁾*I^(1-) 
• 1431884-98-8 (±)-3-methylbut-2-en-1-yl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoatecarboxylate 
• 1431884-99-9 (±)-3,7-dimethylocta-2,6-dien-1-yl 4-(1,3-dioxoisoindolin-2-yl)-(methyl(phenyl)carbamoyl)butanoate 
• 1431884-97-7 (±)-ethyl 4-(1,3-dioxoisoindolin-2-yl)-2-(methyl(phenyl)carbamoyl)butanoate 

Relevant academic research and scientific papers

Facile synthesis of indolizinoindolone, indolylepoxypyrrolooxazole, indolylpyrrolooxazolone and isoindolopyrazinoindolone heterocycles from indole and imide derivatives

Chemo-, regio- and diastereoselective coupling reactions of indole with imide derivatives leading to unique heterocyclic systems are demonstrated. Acid-induced 3-position coupling reactions of indole with cyclic imide derived lactamols followed by acid promoted 2-position cyclizations with the corresponding aldehydes are described to obtain the indolizinoindolones and benzoindolizinoindolones. Base induced 2-position coupling reactions ofN-tosylindole withN-(2-iodoethyl)imides and the subsequent cyclizations provide indolylepoxypyrrolooxazole, indolylpyrrolooxazolone and indolyloxazoloisoindolone. Reductive cleavage of indolyloxazoloisoindolone to the corresponding alcohol followed by mesylation and base promotedN-cyclization affords thein situair-oxidized pentacyclic product hydroxyisoindolopyrazinoindolone. A regioisomeric structural revision of the natural product from 1,2,5,6,7,11c-hexahydro-3H-indolizino[7,8-b]indol-3-one to 1,2,5,6,11,11b-hexahydro-3H-indolizino(8,7-b)indol-3-one is also reported in the present studies focussed on the methodologies for heterocyclic synthesis.

Palladium-Catalyzed (Z)-Selective Allylation of Nitroalkanes: Access to Highly Functionalized Homoallylic Scaffolds

Nitroalkanes undergo decarboxylative allylation in the presence of vinyl-substituted cyclic carbonates, providing a wide variety of functionalized homoallylated compounds with exquisite stereocontrol. This Pd-mediated procedure features operational simplicity, versatile substrate combinations, and also allows for the sequential introduction of different allyl groups in the nitroalkane scaffolds with high levels of stereocontrol through the intermediacy of a (Z)-configured palladacyclic intermediate. As far as we know, the developed protocol is the first general Pd-mediated methodology toward (Z)-configured homoallylic nitroalkanes with attractive functional group diversity.

2H-BENZO[b][1,4]OXAZIN-3(4H)-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS

The present invention discloses 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by ste

Convenient route to primary (Z)-allyl amines and homologs

A convenient two-step procedure for the synthesis of primary (Z)-allyl amines, (Z)-homoallyl amines [(Z)-but-3-enylamines], and (Z)-pent-4-enylamines using the Wittig reaction was achieved. The use of nonstabilized ylides from triphenylphosphonium salt, potassium salt, and apolar solvent produced (Z/E)-geometric isomer ratios generally greater than 1.6. The amine moiety was masked using a phtalimide group that was removed successfully in the last step of the process in two different conditions, NH2NH2/EtOH/rt or CH3NH2/EtOH/rt. However, in some cases, reduction of the C = C double bond in the deprotection with hydrazine was concomitantly observed. Copyright Taylor & Francis Group, LLC.

Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Two structurally distinct series of SCD (Δ9 desaturase) inhibitors (1 and 2) have been previously reported by our group. In the present work, we merged the structural features of the two series. This led to the discovery of compound 5b (CVT-12,012) which