5'-O-(4-monomethoxytrityl)-N⁴-palmitoyl-2'-deoxycytidine-3'-hydrogen phosphonate

Base Information

• Chemical Name: 5'-O-(4-monomethoxytrityl)-N⁴-palmitoyl-2'-deoxycytidine-3'-hydrogen phosphonate
• CAS No.: 152178-68-2
• Molecular Formula: C₄₅H₆₀N₃O₈P
• Molecular Weight: 801.96

Synonyms:5'-O-(4-monomethoxytrityl)-N⁴-palmitoyl-2'-deoxycytidine-3'-hydrogen phosphonate

Chemical Property of 5'-O-(4-monomethoxytrityl)-N⁴-palmitoyl-2'-deoxycytidine-3'-hydrogen phosphonate

Chemical Property:

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Technology Process of 5'-O-(4-monomethoxytrityl)-N⁴-palmitoyl-2'-deoxycytidine-3'-hydrogen phosphonate

There total 1 articles about 5'-O-(4-monomethoxytrityl)-N⁴-palmitoyl-2'-deoxycytidine-3'-hydrogen phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5'-O-(4-monomethoxytrityl)-N4-palmitoyl-2'-deoxycytidine → 5'-O-(4-monomethoxytrityl)-N4-palmitoyl-2'-deoxycytidine-3'-hydrogen phosphonate (152178-68-2)

Guidance literature:

With pyridine; 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one; In 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2004.12.006

Reference yield:

5'-O-(4-monomethoxytrityl)-N4-palmitoyl-2'-deoxycytidine-3'-hydrogen phosphonate (152178-68-2) → acetic acid 5-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-({5-(4-hexadecanoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yloxy}-hydroxy-phosphoryloxymethyl)-tetrahydro-furan-3-yl ester

Guidance literature:

Multi-step reaction with 2 steps

1: pivaloyl chloride; pyridine / 0.05 h / 0 °C

2: I₂ / tetrahydrofuran; pyridine; H₂O / 1 h / 20 °C

With pyridine; iodine; pivaloyl chloride; In tetrahydrofuran; pyridine; water;

DOI:10.1016/j.ejmech.2004.12.006

Reference yield:

5'-O-(4-monomethoxytrityl)-N4-palmitoyl-2'-deoxycytidine-3'-hydrogen phosphonate (152178-68-2) + 3′-O-acetyl-5-fluoro-2′-deoxyuridine (2059-38-3) → C56H71FN5O13P

Guidance literature:

With pyridine; pivaloyl chloride; at 0 ℃; for 0.05h;

DOI:10.1016/j.ejmech.2004.12.006

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