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3′-O-acetyl-5-fluoro-2′-deoxyuridine is a chemical compound that belongs to the class of nucleoside analogs, specifically a derivative of the naturally occurring nucleoside thymidine. 3′-O-acetyl-5-fluoro-2′-deoxyuridine is characterized by the presence of a fluorine atom at the 5-position of the uracil base, a deoxyribose sugar at the 2′ position, and an acetyl group at the 3′ position of the sugar. The fluorination at the 5-position enhances the antiviral activity of the compound, while the acetyl group at the 3′ position serves as a protecting group, which can be removed under specific conditions to yield the corresponding 3′-OH derivative. 3′-O-acetyl-5-fluoro-2′-deoxyuridine has potential applications in medicinal chemistry, particularly in the development of antiviral drugs, due to its ability to interfere with viral replication by acting as a false substrate for viral enzymes.

2059-38-3

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2059-38-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2059-38-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,5 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2059-38:
(6*2)+(5*0)+(4*5)+(3*9)+(2*3)+(1*8)=73
73 % 10 = 3
So 2059-38-3 is a valid CAS Registry Number.

2059-38-3Relevant academic research and scientific papers

Regioselective acylation of nucleosides and their analogs catalyzed by Pseudomonas cepacia lipase: enzyme substrate recognition

Li, Ning,Zong, Min-Hua,Ma, Ding

supporting information; experimental part, p. 1063 - 1068 (2009/04/11)

The substrate recognition of Pseudomonas cepacia lipase in the acylation of nucleosides was investigated by means of rational substrate engineering for the first time. P. cepacia lipase displayed excellent 3′-regioselectivities (96 to >99%) in the lauroyl

Regioselective acylation of nucleosides catalyzed by candida antarctica lipase B: Enzyme substrate recognition

Li, Ning,Zong, Min-Hua,Ma, Ding

supporting information; scheme or table, p. 5375 - 5378 (2009/05/07)

The substrate recognition of Candida antarctica lipase B (CAL-B) in the acylation of nucleosides was revealed through rational substrate engineering for the first time. CAL-B displayed lower activities and excellent 5′-regioselectivities (94 to >99%) in t

Enzymatic regioselective acylation of the 3′-hydroxyl groups of 2′-deoxy-5-fluorouridine (FUdR) and 2′-Deoxy-5-trifiuoromethyluridine (CF3UdR)

Nozaki, Kenji,Uemura, Atuhiko,Yamashita, Jun-Ichi,Yasumoto, Mitsugi

, p. 7327 - 7328 (2007/10/02)

A lipase from Pseudomonas sp. (Amano PS) catalyzes regioselecfive acylation of the 3′-hydroxyl groups of FUdR and CF3UdR.

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