4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide

Base Information

Chemical Name:4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide
CAS No.:1439905-72-2
Molecular Formula:C₁₉H₂₁F₂N₉O
Molecular Weight:429.432
Hs Code.:

Synonyms:4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide

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Chemical Property of 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide

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Technology Process of 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide

There total 13 articles about 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,2R)-3,3-difluorocyclohexane-1,2-diamine dihydrochloride

: 1194973-45-9
4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxamide

: 1439905-72-2
4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide

Guidance literature:: 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxamide; With 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.5h;

(1R,2R)-3,3-difluorocyclohexane-1,2-diamine dihydrochloride; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 2h;

Reference yield:

: 1370261-93-0
ethyl 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxylate

: 1439905-72-2
4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / 1,4-dioxane; water

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h

2.2: 2 h

3.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

3.2: 2 h / 90 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;

Reference yield:

: 1370261-94-1
C₁₄H₁₂N₆O₂S

: 1439905-72-2
4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h

1.2: 2 h

2.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

2.2: 2 h / 90 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;