20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-benzoate 12-methanesulfonate

Base Information

Chemical Name:20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-benzoate 12-methanesulfonate
CAS No.:125259-45-2
Molecular Formula:C₂₉H₄₀O₆S
Molecular Weight:516.699
Hs Code.:

Synonyms:20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-benzoate 12-methanesulfonate

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Chemical Property of 20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-benzoate 12-methanesulfonate

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Technology Process of 20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-benzoate 12-methanesulfonate

There total 7 articles about 20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-benzoate 12-methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 125259-44-1
20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-monobenzoate

: 125259-45-2
20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-benzoate 12-methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at -20 ℃; for 0.5h; Yield given;
DOI:10.1016/S0040-4020(01)89233-4

Reference yield:

: 80680-78-0
23,24-dinor-5β-chol-20(22)-ene-3α,12α-diol 3-monobenzoate

: 125259-45-2
20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-benzoate 12-methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: DEAD, Ph₃P / tetrahydrofuran / Ambient temperature

2: 81 percent / p-toluenesulfonic acid / 7 h / 80 °C

3: piridinium dichromate, mol. sieves 4 Angstroem / CH₂Cl₂ / 0.5 h / Ambient temperature

4: dioxane / 4 h / Irradiation

5: 79 percent / NaBH₄ / ethanol / 0.67 h

6: 99 percent / AcOH, H₂O / tetrahydrofuran / 48 h / Ambient temperature

7: Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With sodium tetrahydroborate; dipyridinium dichromate; 4 A molecular sieve; water; toluene-4-sulfonic acid; acetic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)89233-4

Reference yield:

: 125259-31-6
23,24-dinor-5β-chol-20(22)-ene-3β,12α-diol 3-monobenzoate

: 125259-45-2
20-oxo-12,13-seco-5β-pregn-13-en-3β,12-diol 3-benzoate 12-methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / p-toluenesulfonic acid / 7 h / 80 °C

2: piridinium dichromate, mol. sieves 4 Angstroem / CH₂Cl₂ / 0.5 h / Ambient temperature

3: dioxane / 4 h / Irradiation

4: 79 percent / NaBH₄ / ethanol / 0.67 h

5: 99 percent / AcOH, H₂O / tetrahydrofuran / 48 h / Ambient temperature

6: Et₃N / CH₂Cl₂ / 0.5 h / -20 °C

With sodium tetrahydroborate; dipyridinium dichromate; 4 A molecular sieve; water; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)89233-4