6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane

Base Information

Chemical Name:6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane
CAS No.:162019-04-7
Molecular Formula:C₂₈H₂₆BrCl₃O₄
Molecular Weight:612.775
Hs Code.:

Synonyms:6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane

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Chemical Property of 6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane

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Technology Process of 6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane

There total 12 articles about 6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 162019-03-6
6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindan-1-one

: 162019-04-7
6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane

Guidance literature:: With triethylsilane; trifluoroacetic acid; for 23h; Ambient temperature;
DOI:10.1007/BF01165028

Reference yield:

: 52428-09-8
4,7-dimethoxyindan-1-one

: 162019-04-7
6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / PPA / 45 h / 60 °C

2: 72 percent / NaH / tetrahydrofuran / 2 h / Heating

3: 94 percent / triethylsilane, trifluoroacetic acid / 23 h / Ambient temperature

With triethylsilane; sodium hydride; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1007/BF01165028

Reference yield:

: 38489-74-6
trans-2,5-dimethoxycinnamic acid

: 162019-04-7
6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 24 h

2: 63 percent / polyphosphoric acid / 0.5 h / 57 - 60 °C

3: 85 percent / PPA / 45 h / 60 °C

4: 72 percent / NaH / tetrahydrofuran / 2 h / Heating

5: 94 percent / triethylsilane, trifluoroacetic acid / 23 h / Ambient temperature

With triethylsilane; PPA; hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1007/BF01165028