Technology Process of 6'-formyl-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane
There total 13 articles about 6'-formyl-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 85 percent / PPA / 45 h / 60 °C
2: 72 percent / NaH / tetrahydrofuran / 2 h / Heating
3: 94 percent / triethylsilane, trifluoroacetic acid / 23 h / Ambient temperature
4: 1.) n-BuLi / 1.) THF, -78 deg C, 5 min, 2.) THF, -78 deg C, 1 h
With
triethylsilane; n-butyllithium; sodium hydride; trifluoroacetic acid;
In
tetrahydrofuran;
DOI:10.1007/BF01165028
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / H2 / 5percent Pd/C / tetrahydrofuran / 24 h
2: 63 percent / polyphosphoric acid / 0.5 h / 57 - 60 °C
3: 85 percent / PPA / 45 h / 60 °C
4: 72 percent / NaH / tetrahydrofuran / 2 h / Heating
5: 94 percent / triethylsilane, trifluoroacetic acid / 23 h / Ambient temperature
6: 1.) n-BuLi / 1.) THF, -78 deg C, 5 min, 2.) THF, -78 deg C, 1 h
With
triethylsilane; n-butyllithium; PPA; hydrogen; sodium hydride; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran;
DOI:10.1007/BF01165028
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 79.5 percent / piperidine, piridine / 4 h / 110 °C
2: 100 percent / H2 / 5percent Pd/C / tetrahydrofuran / 24 h
3: 63 percent / polyphosphoric acid / 0.5 h / 57 - 60 °C
4: 85 percent / PPA / 45 h / 60 °C
5: 72 percent / NaH / tetrahydrofuran / 2 h / Heating
6: 94 percent / triethylsilane, trifluoroacetic acid / 23 h / Ambient temperature
7: 1.) n-BuLi / 1.) THF, -78 deg C, 5 min, 2.) THF, -78 deg C, 1 h
With
piperidine; pyridine; triethylsilane; n-butyllithium; PPA; hydrogen; sodium hydride; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran;
DOI:10.1007/BF01165028
