1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide

Base Information

Chemical Name:1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide
CAS No.:223719-80-0
Molecular Formula:C₁₉H₂₀BrN₃O
Molecular Weight:386.291
Hs Code.:

1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine-3-carboxylic acid amide

Synonyms:1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide

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Chemical Property of 1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide

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Technology Process of 1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide

There total 5 articles about 1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 169882-13-7
1-(2-bromo-4-isopropylphenyl)-3-cyano-4,6-dimethyl-7-azaindole

: 223719-80-0
1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide

Guidance literature:: With dihydrogen peroxide; potassium carbonate; In dimethyl sulfoxide; for 16h; Ambient temperature;
DOI:10.1021/jm980223o

Reference yield:

: 51605-97-1
2-bromo-4-isopropylaniline

: 223719-80-0
1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / gl. AcOH / ethanol / 2 h / Heating

2: 59 percent / t-BuOK / ethanol; tetrahydrofuran / 16 h / Ambient temperature

3: 78 percent / conc. HCl / ethanol / 4 h / Heating

4: 89 percent / K₂CO₃, 30 percent H₂O₂ / dimethylsulfoxide / 16 h / Ambient temperature

With hydrogenchloride; potassium tert-butylate; dihydrogen peroxide; potassium carbonate; acetic acid; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm980223o

Reference yield:

: potassium salt of formylsuccinonitrile

: 223719-80-0
1-(2-bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / gl. AcOH / ethanol / 2 h / Heating

2: 59 percent / t-BuOK / ethanol; tetrahydrofuran / 16 h / Ambient temperature

3: 78 percent / conc. HCl / ethanol / 4 h / Heating

4: 89 percent / K₂CO₃, 30 percent H₂O₂ / dimethylsulfoxide / 16 h / Ambient temperature

With hydrogenchloride; potassium tert-butylate; dihydrogen peroxide; potassium carbonate; acetic acid; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm980223o