51605-97-1

Basic information

• Product Name: 2-BROMO-4-ISOPROPYLANILINE
• Synonyms: 2-BROMO-4-ISOPROPYLANILINE;2-BROMO-4-ISOPROPYL-PHENYLAMINE;2-(4Amino-3bromophenyl)propane;Benzenamine, 2-bromo-4-(1-methylethyl)-;2-broMo-4-(propan-2-yl)aniline;2-Bromo-4-(prop-2-yl)aniline;2-Bromo-4-isopropylbenzenamine;4-Isopropyl-2-bromoaniline
• CAS NO: 51605-97-1
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.1
• Product Categories: Anilines, Amides & Amines;Bromine Compounds
• Mol File: 51605-97-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 116 °C
• Flash Point: 116-118°C/3mm
• Appearance: /
• Density: 1.35
• Vapor Pressure: 0.00631mmHg at 25°C
• Refractive Index: 1.5750 to 1.5790
• Storage Temp.: Room temperature.
• PKA: 2.94±0.10(Predicted)
• Water Solubility: Miscible with dioxane and ethoxyethanol. Immiscible with water.
• BRN: 2638470
• CAS DataBase Reference: 2-BROMO-4-ISOPROPYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-ISOPROPYLANILINE(51605-97-1)
• EPA Substance Registry System: 2-BROMO-4-ISOPROPYLANILINE(51605-97-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• RIDADR: UN2810
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 51605-97-1(Hazardous Substances Data)

Usage

Uses

2-Bromo-4-isopropylaniline is involved in the preparation of 4-(5-aryl-1, 2, 3, 6-tetrahydropyridino) pyrimidine derivatives and 4-substituted-2-anilinopyrimidine derivatives, which find application as corticotropin releasing factor (CRF) antagonists.

InChI:InChI=1/C9H12BrN/c1-6(2)7-3-4-9(11)8(10)5-7/h3-6H,11H2,1-2H3

Upstream product

• 5702-74-9 N-(4-iso-propylphenyl)acetamide 
• 99-88-7 4-Isopropylaniline 

Downstream Products

• 5433-01-2 1-bromo-3-isopropylbenzene 
• 219840-92-3 N-[2-Bromo-4-(1-methylethyl)phenyl]-4-(2,4,6-trimethylphenyl)-6-methyl-2-pyrimidineamine 
• 220953-53-7 N²-(2-bromo-4-isopropylphenyl)-N⁴-butyl-N⁴-ethyl-6-methyl-3-nitropyridine-2,4-diamine 
• 220953-54-8 2--4-(N,N-bis(methoxyethyl)amino)-6-methyl-3-nitropyridine 
• 220953-41-3 4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylcarboxamido)butylamino>-2-methyl-5-nitropyrimidin-4-amine 
• 197803-32-0 N²-(2-bromo-4-isopropyl-phenyl)-6-methyl-3-nitro-N⁴-(1-propyl-butyl)-pyridine-2,4-diamine 
• 444325-54-6 N-(2-bromo-4-isopropyl-phenyl)-2-chloro-acetamide 
• 856171-16-9 2-chloro-6-isopropyl-benzothiazole 
• 68748-07-2 N-<2-bromo-4-(1-methylethyl)phenyl>acetamide 
• 231296-86-9 methyl trans-5-isopropyl-2-aminocinnamate 
• 197799-22-7 (+/-)-N-[2-bromo-4-(1-methylethyl)phenyl]-1-(1-ethylpentyl)-6-methyl-1H-1,2,3-triazolo[4,5-c] pyridin-4-amine 
• 197799-12-5 N-[2-bromo-4-(1-methylethyl)phenyl]-1-(1-ethylpropyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine 
• 288626-13-1 N-(2-bromo-4-(1-methylethyl)phenyl)-4-methyl-2-pyrimidinamine 

Relevant articles and documents

Novel phenylcarbazole type organic compounds and an organic electroluminescent device comprising the same

An organic compound represented by chemical formula 1 and an organic light emitting device including the same are provided. Chemical Formula 1.

Environmentally benign indole-catalyzed position-selective halogenation of thioarenes and other aromatics

Halogenated aromatic compounds are the cores of many pharmaceutical, agricultural and chemical products but they are commonly prepared using electrophilic halogenation reactions in non-green chlorinated solvents under harsh conditions. A separate problem happens in the aromatic halogenation of thioarenes because they readily undergo oxidative side-reactions. Herein we report an environmentally benign electrophilic bromination of aromatics using an indole-catalytic protocol, which is suitable for a wide range of substrates including thioarenes.

Copper-Catalyzed Enantioselective Conjugate Addition to α,β-Unsaturated Aldehydes with Various Organometallic Reagents

β-Substituted aldehydes constitute a very important class of compounds found in nature. Synthesis of this motif can be envisioned by C-C bond formation on enals. For this purpose, we report herein the development of enantioselective copper-catalyzed conjugate addition of various organometallic reagents to α,β-unsaturated aldehydes with (R)-H8BINAP, (R)-TolBINAP, and (R)-SEGPHOS as chiral ligands. Three sets of conditions were successfully developed and several enals were used. Reactivity and regio- and enantioselectivities were strongly dependent on reaction conditions and substrates. Good to excellent regio- and enantioselectivities were obtained with zinc reagents R2Zn and aluminum reagents R3Al. However, the asymmetric conjugate addition of Grignard reagents afforded only moderate to good regio- and enantioselectivities.