diethyl 2,3-dihydro-1-(4-hydroxyphenyl)-2-oxo-1H-indole-3,3-dicarboxylate

Base Information

• Chemical Name: diethyl 2,3-dihydro-1-(4-hydroxyphenyl)-2-oxo-1H-indole-3,3-dicarboxylate
• CAS No.: 78394-21-5
• Molecular Formula: C₂₀H₁₉NO₆
• Molecular Weight: 369.374

Synonyms:diethyl 2,3-dihydro-1-(4-hydroxyphenyl)-2-oxo-1H-indole-3,3-dicarboxylate

Chemical Property of diethyl 2,3-dihydro-1-(4-hydroxyphenyl)-2-oxo-1H-indole-3,3-dicarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of diethyl 2,3-dihydro-1-(4-hydroxyphenyl)-2-oxo-1H-indole-3,3-dicarboxylate

There total 2 articles about diethyl 2,3-dihydro-1-(4-hydroxyphenyl)-2-oxo-1H-indole-3,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

N-phenyl-p-benzoquinone imine N-oxide (2206-58-8) + acetylenedicarboxylic acid diethyl ester (762-21-0) → diethyl 2,3-dihydro-1-(4-hydroxyphenyl)-2-oxo-1H-indole-3,3-dicarboxylate (78394-21-5)

Guidance literature:

In chloroform; Heating;

DOI:10.1039/P19810000712

Reference yield:

diphenylamine (122-39-4) → diethyl 2,3-dihydro-1-(4-hydroxyphenyl)-2-oxo-1H-indole-3,3-dicarboxylate (78394-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: two stage oxidation

2: 40 percent / CHCl₃ / Heating

In chloroform;

DOI:10.1039/P19810000712

Reference yield: 89.0%

diethyl 2,3-dihydro-1-(4-hydroxyphenyl)-2-oxo-1H-indole-3,3-dicarboxylate (78394-21-5) → ethyl 2-hydrazino-1-(4-hydroxyphenyl)-1H-indol-3-carboxylate (78394-26-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1039/P19810000712

upstream raw materials:

N-phenyl-p-benzoquinone imine N-oxide

acetylenedicarboxylic acid diethyl ester

diphenylamine

Downstream raw materials:

1-(4-hydroxyphenyl)-1H,3H-indol-2-one

ethyl 2-hydrazino-1-(4-hydroxyphenyl)-1H-indol-3-carboxylate

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