acetic acid [(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamoyl]-methyl ester

Base Information

Chemical Name:acetic acid [(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamoyl]-methyl ester
CAS No.:949904-67-0
Molecular Formula:C₁₃H₁₉F₂NO₄
Molecular Weight:291.295
Hs Code.:

Synonyms:acetic acid [(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamoyl]-methyl ester

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Chemical Property of acetic acid [(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamoyl]-methyl ester

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Technology Process of acetic acid [(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamoyl]-methyl ester

There total 3 articles about acetic acid [(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamoyl]-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₂₁F₂NO₄

: 949904-67-0
acetic acid [(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamoyl]-methyl ester

Guidance literature:: With sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.9b00406

Reference yield:

: 1123661-37-9
2-[(4,4-difluorocyclohexylmethyl)amino]ethanol

: 949904-67-0
acetic acid [(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamoyl]-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/acsmedchemlett.9b00406

Reference yield:

: 194427-24-2
(4,4-difluorocyclohexyl)methyl methanesulfonate

: 949904-67-0
acetic acid [(4,4-difluoro-cyclohexylmethyl)-(2-oxo-ethyl)-carbamoyl]-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 2 h / 75 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1021/acsmedchemlett.9b00406